Wrapper Function to obtain scores via liana_pipe
Arguments
- method
name of the method to be called
- lr_res
ligand-receptor DE results and other stats between clusters
- ...
Arguments passed on to
liana_pipe
sce
SingleCellExperiment Object
op_resource
resource tibble obtained via liana::select_resource
assay
assay to be used ("RNA" by default)
assay.type
- the type of data to be used to calculate the means (logcounts by default), available options are: "counts" and "logcounts"
verbose
logical for verbosity
cell.adj
cell adjacency tibble/dataframe /w weights by which we will `multiply` the relevant columns. Any cell pairs with a weights of 0 will be filtered out. Note that if working with LIANA's default methods, we suggest weights >= 0 & =< 1. This ensure that all methods' score will be meaningfully weighed without changing the interpretation of their scores, thus allow one to filter SCA, rank NATMI, etc.
test.type
String specifying the type of pairwise test to perform - a t-test with
"t"
, a Wilcoxon rank sum test with"wilcox"
, or a binomial test with"binom"
.pval.type
A string specifying how p-values are to be combined across pairwise comparisons for a given group/cluster.
base
base for conversion from log-tranformed ~CPM back to ~CPM.