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Multicellular factor analysis for tissue-state representations

mc-ASTRA (mc_astra, commonly imported as mca) provides a bridge between single-cell data analysis workflows from scverse, factor-based models from MOFA-FLEX, and prior knowledge to generate tissue-centric descriptions from single-cell data.

This package facilitates the implementation of Multicellular Factor Analysis by providing functions to process and format single-cell data into a multi-view format, together with additional visualization and downstream tasks to analyse and interpret multicellular programs.

Citation

  • Ramirez Flores RO, Lanzer JD, Dimitrov D, Velten B, Saez-Rodriguez J. 2023. Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease. eLife 12:e93161. https://elifesciences.org/articles/93161