Data generated from 10 random layouts of four cell types and empty space on 100-by-100 grid by simulating a two-dimensional cellular automata model that focuses on signaling events. Cell growth, division, motility and death are neglected. The intracellular processes involve two layers, first the ligand activation of signaling hubs and ligand production/secretion regulated by proteins. The model simulates the production, diffusion, degradation and interactions of 11 molecular species. Ligands are produced in each cell-type based on the activity level of their production nodes and then freely diffuse, degrade or interact with other cells on the grid. Other molecular species involved in signaling are localised in the intracellular space and their activity depends on ligand binding and intracellular wiring.
Usage
data("synthetic")Format
A named list of length 10. Each list item is a tibble that
corresponds to a simulation of one random layout with information about each
cell in rows described by the following 14 variables:
- row, col
location of the cell on the grid
- ligA, ligB, ligC, ligD
expression of ligands
- protE, protF
expression of intracellular proteins
- prodA, prodB, prodC, prodD
expression of regulatory proteins
- type
cell type id