Comprehensive Prior Knowledge Network (PKN), which combines signaling and metabolic interaction networks. The network was constructed using the Recon3D and STITCH metabolic networks as well as the signaling network from OmniPath.
An object of class “
tibble” with 117065 rows
(interactions) and three variables:
Source node, either metabolite or protein
Type of interaction, 1 = Activation, -1 = Inhibition
Target node, either metabolite or protein
The network is available in Omnipath: https://metapkn.omnipathdb.org/metapkn__20200122.txt, the scripts used for the build of the network are available under https://github.com/saezlab/Meta_PKN.
Dugourd, A., Kuppe, C. and Sciacovelli, M. et. al. (2021) Molecular Systems Biology. 17, e9730.
meta_pkn = meta_network#> Error in eval(expr, envir, enclos): object 'meta_network' not found