This signaling network is the reduced COSMOS network solution obtained in the case study of the COSMOS paper. Here, this network solution is reused as an exemplary input prior knowledge network (PKN).
An object of class “
data.frame” with 19 rows
(interactions) and three variables:
Source node, either metabolite or protein
Type of interaction, 1 = Activation, -1 = Inhibition
Target node, either metabolite or protein
The network data are available on github: https://github.com/saezlab/COSMOS_MSB/tree/main/results/COSMOS_result/COSMOS_res_session.RData. The toy_network is the combined network of the COSMOS network solutions CARNIVAL_Result2 and CARNIVAL_Result_rerun subsequently reduced to 19 exemplary nodes.
Dugourd, A., Kuppe, C. and Sciacovelli, M. et. al. (2021) Molecular Systems Biology. 17, e9730.
toy_pkn = toy_network