Signaling

Inferring signaling networks from omics data is a challenging task due to the complexity of the underlying biological processes. CORNETO provides a set of tools to infer and contextualize signaling networks from omics data and prior knowledge.

• CARNIVAL
  • Creating a toy example
  • CarnivalFlow
  • Carnival ILP
  • Old implementation
• Multi-sample CARNIVAL
  • Toy example
  • Multi-sample CARNIVAL
  • Plotting solutions on top of the PKN
  • Single sample using the same multi-sample method
• Acyclic boolean models of cell signaling (experimental)
• Introduction to a Boolean model
  • Inhibition: !EGF activates RAS
  • Inhibition with AND gates
• Complex case study with inhibition